Preparation and implantation alzet osmotic pumps sop9 osmotic pumps manufactured by alza corporation palo alto, ca are designed for constant rate delivery of test solutions over a. Specify the model, order number and quantity of pumps you require. Alzet osmotic pumps are miniature, implantable pumps used for research in mice. Alzet pumps are miniature, osmotic infusion pumps for the. Longterm morphine delivery via slow release morphine. Miniosmotic pumps represent an ideal system for prolonged direct drug delivery into the brain by circumventing both low accessibility to the brain and also peaks of drug concentration, as the delivery of the drug happens directly into a targeted place in the brain and at a fixed flow rate determined by the pump model that is chosen 2,6,7. Download our whitepaper, advancing cancer treatments with alzet. Subcutaneous angiotensin ii infusion using osmotic pumps.
These minipumps provide researchers with a method for controlled and continuous agent delivery in vivo. Maximize therapeutic efficacy and reduce adverse effects. This in vitro testing method gives a good measure of reproducibility over time, both within pumps and. Free access to all jove education videos until june 15. This video shows the parts of the pump and describes how the pump operates to enable continuous delivery of experimental agents. Durect manufactures and sells alzet osmotic pumps and accessories on a worldwide basis. Durect corporation alzet osmotic no 1004 pump alzet. Mini osmotic pumps alzet 2001, 2004, 2006 or micro osmotic pumps alzet 1004.
This video article jove describes a method for targeted administration of drugs to the central nervous system by either continuous delivery using alzet osmotic pumps or performing bolus injections into the right lateral ventricle of mice. Alzet osmotic pumps implantable infusion pumps for. Alzet resource videos osmotic pump mechanism on vimeo. Find the durect media kit here, including logos and press contacts. To examine the relationship between aldosterone and myocardial fibrosis, collagen volume fraction of the left and right ventricles were analyzed by videodensitometry of sirius red stained tissue in the following rat models. Watch the above overview video to learn more about the technology, benefits, and. Plasma concentration, analgesia, and naloxoneprecipitated withdrawal.
This video describes the inner parts of an alzet pump and how they operate to enable continuous delivery of experimental agents. As the core absorbs water, it expands in volume, which pushes the drug solution out. In addition, durect has a video available on cd or for download that demonstrates surgical techniques and special applications for the use of alzet osmotic pumps. Alzet pumps have been used successfully in experimental biology research for pharmacokinetic analysis, behavior and growth research, physiology, and other applications requiring a precise drug delivery system. This 20 minute video describes the alzet pump mechanism, and the advantages of continuous infusion over frequent injections. Individual lots of pumps may vary from this target within limits. Osmotic pumps can be used for systemic administration. Checklist and tips for successful use of alzet osmotic pumps. Osmotic pumps are miniature infusion pumps for the continuous dosing of laboratory animals. Subcutaneous angiotensin ii infusion using osmotic pumps induces. Alzet osmotic pumps are miniature infusion systems that deliver test agents at. Microosmotic pumps for continuous release of the tyrosine. Preparation of alzet osmotic pumps for subcutaneous implantation reagentssupplies 1.
This article introduces a standard protocol used to induce aortic aneurysms via subcutaneous infusion of angiotensin ii angii from implanted osmotic pumps. Osmotic pumps continuously deliver compounds at a constant rate into small animals. To achieve widespread gene knockdown or splicing in the cns of mice, the asos can be delivered into the brain using two separate routes of administration, both of which we demonstrate in the video. They offer a simple, convenient and reliable alternative to repetitive videos in alzet osmotic pumps on vimeo. Empty reservoir within the core of the pump is filled with the drug or hormone solution to be delivered and is surrounded by salt chamber with impermeable layer between them it is an implantable osmotic pumps for laboratory animal the pump are used to.
Over 12,000 publications attest to the reliability of alzet pumps in preclinical research. We market the alzet product line directly in the u. Longterm morphine delivery via slow release morphine pellets or osmotic pumps. This video provides an overview of alzet pump overview on vimeo. We will continue to respond to the demands for new technology and commit to provide products that assist you. Implantation of miniosmotic pumps and delivery of tract. Specify the model, order number and quantity of pumps. This video demonstrates subcutaneous and intraperitoneal implantations, intravenous infusion via the external jugular vein, localized administration into the central nervous system.
Lab animals this video shows lab animals implanted with alzet pumps, and describes how alzet pumps improve animal welfare by reducing the stress caused by repetitive injections and frequent animal handling. The nominal performance is a target for all pumps manufactured. Subcutaneous neurotrophin 4 infusion using osmotic pumps or direct muscular injection enhances aging rat laryngeal muscles richard d. Implantation of osmotic pumps in rodents university of kentucky.
Alzet pumps are small, implantable devices for continuous dosing of unrestrained lab animals. To view the presentation full screen simply click the square icon located in the bottomright corner of the video. Alzet osmotic pumps have been a part of successful research for over 40 years. Alzet surgical implantation procedures video in alzet osmotic. Alzet pumps are a simple, convenient and reliable method for continuous dosing of laboratory animals, including mice and rats. After filling with compund solution, implantation can be performed in just minutes. This video describes the subcutaneous and intraperitoneal implantation procedures. Watch this short video for an overview of the alzet technology, benefits and applications. Osmotic pumps release drug at a rate that is independent of the ph and hydrodynamics of the dissolution medium. Subcutaneous angiotensin ii infusion using osmotic pumps induces aortic aneurysms in mice hong lu 1, deborah a.
This video describes proper filling of the alzet pump and and surgical techniques for implantation in rats and mice including subcutaneous and interperitoneal. In addition, durect has a video available on cd or for download that demonstrates surgical techniques and special applications for the use of alzet osmotic. Osmotic pumps consist of an inner core containing drug and osmogens, coated with a semipermeable membrane. Articular cavity, blood vessels, bone, brain solid tissue, brain ventricles, ear, eye, muscle, nerves, spinal cord, stomach, and tumors. You may wish to print this form before submitting your. They offer a simple, convenient and reliable alternative to repetitive injections, which require frequent animal handling. Alzet pumps have been used to target delivery to a wide variety of sites including the spinal cord, spleen, liver, organ or tissue transplants, and wound. Osmotic drug delivery system as a part of modified release. You may wish to print this form before submitting your order so you have a copy for your records. Subcutaneous neurotrophin 4 infusion using osmotic pumps. Alzet pumps can also be used for targeted delivery, where the effects of a drug or test agent are localized in a particular tissue or organ, by means of a catheter.
Durect corporation alzet osmotic pump model 1002 alzet. Oral osmotic drug delivery system classification of osmotic dds 8. Durect estimates the pumping rate of alzet osmotic pumps by measuring their pumping rate in vitro in 0. Alzet customer service will contact you by the next business day to confirm your order and to supply pricing information. Alzet pumps deliver by the process of osmotic displacement. A filling needle is included in the box with osmotic pumps. As the core absorbs water, it expands in volume, which pushes the drug solution out through the delivery ports. Video article demonstrating icv delivery to the mouse cns. Tips for successful use this webinar will provide researchers with insider tips everyone should know for planning and executing their animal dosing studies with alzet pumps.
Pdf download channels carriers and pumps second edition an introduction to. Download article pdf download research materials list. Common routes of administration requiring use of a catheter. Watch this short video to learn how alzet osmotic pumps work to enable reliable and continuous delivery.
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